CBD Reduces Inflammation, Stiffness and Pain
CBD can relieve the symptoms of pain and stiffness by regulating several mechanisms of inflammation.
The first thing that We should all learn about CBD is it inhibits the breakdown of Anandamide – your endogenous (already in your body) cannabinoid. Keeping your internal Bliss molecule high and around longer is good for everyone, but especially those with chronic pain.
CBD acts as an immune system modulator. By behaving like a Prostaglandin, CBD can boost a weak immune system and down-regulate an overactive one.
CBD binds to TRPV1 or “TRiP 1” receptors, which are known to mediate pain perception, inflammatory response and body temperature. TRiP 1 receptors are also called “vanilloid receptor,” because Vanilla contains Eugenol. Eugenol is a terpene that has been used for the treatment of pain for centuries. As a patient, I often mix my CBD with Vanilla extract.
The inflammatory response in people with Autoimmune disease is often overly aggressive and erratic. The Trip-1 receptor mediates inflammation of your B-Cells and T-Cells. The front line of your reactive immune system. I always imagine these cells as if they are the Ambulance, Police, and Fire Truck. CBD can soothe an overactive immune system and keep your joints, gut, and brain feeling like a happy little down instead of a burning city block.
These important receptors are in the connective tissue and fascia of your body. When you are in pain, your body naturally tenses that area to protect itself from further injury. This ‘splinting’ reflex also happens with people who have experienced trauma and anxiety.
By consistently down-regulating this innate splinting tendency most people feel more relaxed, present, emotionally available and self-reflective.
It also explains why people can do so well with such a small dose
Anandamide, your endogenous cannabinoid, is also a TRiP1 agonist, or activator. This can create a positive feedback loop and a more complete interaction with every tissue in your body. Especially your fascia.
Myrcene and Beta-Caryophyllene are the best entourage allies for this effect
CBD can also influence inflammation and pain perception through your Adenosine receptors. Adenosine is the molecule that caffeine blocks to keep you more alert. Specifically, CBD ’s anti-inflammatory and anti-anxiety effects are due to inhibition of Adenosine reuptake. By delaying the reuptake of this neurotransmitter, CBD helps maintain higher Adenosine levels in your brain, which regulates pain perception and can greatly reduce anxiety and some aspects of PTSD.
Some people enjoy the combination of CBD and Coffee, Tea, or Hot Chocolate. CBD slows and augments the effects of caffeine, improving focus and reduces pain. Some people dislike the combination, saying they felt ungrounded. I find chocolate to be the best source of caffeine to combine with CBD. Let me know what you have experienced.
CBD, Inflammation, Alzheimer’s and Cancer
There are two more aspects to how CBD can affect the human metabolism and immune system. They have more research about Cancer and Alzheimer’s Disease but are also immune-regulating in general. Immune regulation is an essential part of keeping inflammation down, reducing pain and many other symptoms.
CBD also promotes an immune-modulating and anti-cancer effect by activating your PPARs (Peroxisome Proliferator-Activated Receptors) that are located on the surface of each of your cell’s nucleus. Activating your PPARs activates enzymes that reduce intracellular inflammation and degrades amyloid-beta plaque, the neurological scarring that is associated with the development of Alzheimer’s disease.
CBD is a GPR55 “Grip55’ antagonist, which means that CBD blocks the activity of your Grip55 receptors. When you block your Grip55 receptor, you will down-regulate inflammation, cancer cell proliferation, bone reabsorption, and decrease Alzheimer’s symptoms.
Chronic inflammation and stress promote Osteoclast Cell function, which increases bone reabsorption. Bone reabsorption is part of being Tissue Catabolic and of ageing. It is the process that happens when your body needs vital proteins and minerals outside of your bones in a hurry. People with an overactive Grip55 receptor are more likely to experience Osteoporosis.
There is some evidence that a highly stimulated Grip55, also promotes cancer cell proliferation or faster tumour growth. Keeping this receptor working slow and steady is an obvious strategy for prevention, especially for women.
Both CBD and THC bind to and activate the CB2 receptor, which has an anti-inflammatory, adaptive, and immune-modulating effect.
Autoimmune patients who are looking for long-term solutions and preventative strategies, especially those wanting to avoid just suppressing their immune system, CBD is definitely some to look into.